Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8;21), 5q-, -Y karyotype

Aslan V., Akay O., Durak B. , Kabukcuoglu S., Gulbas Z.

LEUKEMIA & LYMPHOMA, vol.43, no.8, pp.1683-1685, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1080/1042819021000003036
  • Title of Journal : LEUKEMIA & LYMPHOMA
  • Page Numbers: pp.1683-1685


A 31-year-old man was admitted to hospital with onset of difficulty in walking and urinary incontinence, leading to the diagnosis of Langerhans cell histiocytosis (LCH) which was replacing a thoracic vertebra. Four months after the completion of radiation therapy, he was referred to our department with persistent fever and severe pyogenic ulceration mainly affecting the right-hip. A diagnosis of acute non-lymphoblastic leukemia (ANLL) was made. Cytogenetic studies showed 45,X, t(8; 21), 5q-, -Y. We report this case because, development of acute leukemia after LCH is rare and the literature searched for any cytogenetic study in these kind of cases yielded no data.