Langerhans cell histiocytosis with transformation to acute leukemia showing 45,X, t(8;21), 5q-, -Y karyotype

Aslan V., Akay O., Durak B., Kabukcuoglu S., Gulbas Z.

LEUKEMIA & LYMPHOMA, cilt.43, sa.8, ss.1683-1685, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1080/1042819021000003036
  • Dergi Adı: LEUKEMIA & LYMPHOMA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1683-1685
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

A 31-year-old man was admitted to hospital with onset of difficulty in walking and urinary incontinence, leading to the diagnosis of Langerhans cell histiocytosis (LCH) which was replacing a thoracic vertebra. Four months after the completion of radiation therapy, he was referred to our department with persistent fever and severe pyogenic ulceration mainly affecting the right-hip. A diagnosis of acute non-lymphoblastic leukemia (ANLL) was made. Cytogenetic studies showed 45,X, t(8; 21), 5q-, -Y. We report this case because, development of acute leukemia after LCH is rare and the literature searched for any cytogenetic study in these kind of cases yielded no data.