© The British Society of Developmental Disabilities 2021.The purpose of this study was to determine whether the augmented reality in children with autism spectrum disorder is an evidence-based practice. For this purpose, a systematic literature review was conducted for determining research that implemented the augmented reality. The review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. As a result of the review, nine single-case experimental design (SCED) research that met the inclusion criteria were analyzed using the quality indicators. At the end of the quality evaluation, the effect size of eight SCED research that were determined to have evidence of a strong or adequate quality was calculated by using Tau-U. The results of the study revealed that the augmented reality was a promising and highly effective intervention (Tau U = 0.98) in teaching new skills for children with autism spectrum disorder.