Gallic Acid Reduces Experimental Colitis in Rats by Downregulation of Cathepsin and Oxidative Stress

Bayramoğlu G., Şentürk H., Kanbak G., Canbek M., Bayramoglu A., Dokumacıoğlu E., ...Daha Fazla

ERCIYES MEDICAL JOURNAL, cilt.42, sa.2, ss.213-217, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/etd.2020.42713
  • Dergi Adı: ERCIYES MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.213-217
  • Anahtar Kelimeler: Cathepsin, colitis, gallic acid, myleperoxidase, oxidative stress, TNBS-INDUCED COLITIS, ULCERATIVE-COLITIS, MYELOPEROXIDASE, DEFENSE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease (IBD) with common, repetitive inflammation of the colon and rectum, which is highly defined by loss of blood on colon mucosa, ulceration and acute inflammation. The present study aimed to investigate the potential protective effects of gallic acid (GA) through a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rat model, using biochemical and histopathological parameters.