Gallic Acid Reduces Experimental Colitis in Rats by Downregulation of Cathepsin and Oxidative Stress


Bayramoğlu G., Şentürk H., Kanbak G., Canbek M., Bayramoglu A., Dokumacıoğlu E., ...More

ERCIYES MEDICAL JOURNAL, vol.42, no.2, pp.213-217, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.14744/etd.2020.42713
  • Journal Name: ERCIYES MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-217
  • Keywords: Cathepsin, colitis, gallic acid, myleperoxidase, oxidative stress, TNBS-INDUCED COLITIS, ULCERATIVE-COLITIS, MYELOPEROXIDASE, DEFENSE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease (IBD) with common, repetitive inflammation of the colon and rectum, which is highly defined by loss of blood on colon mucosa, ulceration and acute inflammation. The present study aimed to investigate the potential protective effects of gallic acid (GA) through a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rat model, using biochemical and histopathological parameters.