Background: Pathogenesis of anaemia of chronic disease is multifactorial. It is related with corrupted erythropoietin-dependent erythropoiesis due to C-reactive protein, and pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. It is also related with decreased red cell survival and impaired iron mobilization. Hepcidin level in iron deficiency anaemia is low than controls but it is high in patients with chronic renal failure. Pro-inflammatory cytokines are associated with the pathogenesis of rheumatoid arthritis and development of anaemia in rheumatoid arthritis.