Clinical significance of serum IL-6, TNF-alpha, Hepcidin, and EPO levels in anaemia of chronic disease and iron deficiency anaemia: The laboratory indicators for anaemia


ÜSKÜDAR TEKE H., ÜSKÜDAR CANSU D., YILDIZ P., Temiz G., BAL C.

BIOMEDICAL RESEARCH-INDIA, vol.28, no.6, pp.2704-2710, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2017
  • Journal Name: BIOMEDICAL RESEARCH-INDIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.2704-2710
  • Keywords: Anemia, Chronic disease, Cytokine, CHRONIC KIDNEY-DISEASE, RHEUMATOID-ARTHRITIS, TRANSFERRIN RECEPTOR, RENAL-DISEASE, ERYTHROPOIETIN, INFLAMMATION, HEMODIALYSIS, PROTEIN, PEPTIDE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Pathogenesis of anaemia of chronic disease is multifactorial. It is related with corrupted erythropoietin-dependent erythropoiesis due to C-reactive protein, and pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. It is also related with decreased red cell survival and impaired iron mobilization. Hepcidin level in iron deficiency anaemia is low than controls but it is high in patients with chronic renal failure. Pro-inflammatory cytokines are associated with the pathogenesis of rheumatoid arthritis and development of anaemia in rheumatoid arthritis.