Serum Prolidase Enzyme Activity Level: Not a Predictive Biomarker for Epilepsy

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Ayas Z. O., Kotan D., AKDOĞAN M., Gunel M. E.

EURASIAN JOURNAL OF MEDICINE, vol.51, no.1, pp.27-30, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5152/eurasianjmed.2018.18183
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.27-30
  • Eskisehir Osmangazi University Affiliated: Yes


Objective: Oxidative stress (OS) and inflammation are considered responsible for the pathogenesis of epilepsy. Prolidase has an extremely important role in proline recycling for collagen synthesis. Higher than normal proline levels have been shown to increase OS. Furthermore, prolidase activity is associated with inflammation during fibrotic process. No study has yet investigated the relationship between epilepsy and prolidase enzyme activity (PEA). In this study, we aimed to contribute to the existing literature by assessing postictal PEA levels, which are correlated with inflammation and OS, to determine whether PEA levels may be used as a biomarker for epilepsy.