Voltammetry of trazodone by platinum electrode and its determination in tablets using DP technique in the rotating conditions


Dogrukol-Ak D., Zaimoglu V., Tuncel M.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.7, sa.3, ss.215-220, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Konu: 3
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0928-0987(98)00021-9
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.215-220

Özet

The voltammetric behaviors of trazodone using a platinum electrode in stationary or rotating conditions and its determination in tablets by DP rotating electrodes are described in this study. The experiments were conducted in the supporting electrolyte consisting of 0.2 M KCl and 0.2 M acetate or phosphate buffer. No adsorption was observed at +300 mV. The factor affecting the voltammetric current was diffusional in the range of 200-2000 rpm for rotating, and 2-10 mV potential rate for stationary conditions; and the calibration dependence was linear between 1x10(-5)-5x10(-5) M trazodone solutions. The detection limit was found to be 2.5x10(-6) M (s(b)=5.03, n=5) for stationary and 1.7x10(-6) M (s(b)=2.12, n=5) for rotating electode assuming a signal to noise ratio of 3. According to the statistical evaluations, acceptable results were obtained at the 95% probability level. Therefore, the proposed method is practicable, sensitive and accurate for the analysis of trazodone preparations in quality control laboratories. (C) 1999 Elsevier Science B.V. All rights reserved.