Akademik Veri Yönetim Sistemi
57th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition, Helsinki, Finlandiya, 14 - 17 Mayıs 2025, ss.443-444, (Tam Metin Bildiri)
Objectives and Study: Helicobacter pylori (H. pylori) prevalence has been studied in various pediatric populations; however,
its relationship with allergic proctocolitis remains unclear. This multicenter study aimed to evaluate the prevalence of H. pylori
in infants with allergic proctocolitis compared to healthy controls in Turkey, while considering maternal and infant-related
factors that could influence colonization.
Methods: Infants aged 1 month to 1 year from seven regions in Turkey were included. Stool samples from 96 infants
diagnosed with allergic proctocolitis (AP) in allergy clinics and their mothers (when available) were analyzed for H. pylori
using PCR. A control group of 51 age- and sex-matched healthy infants and their mothers (when available) attending wellbaby
clinics was also included. Maternal allergic diseases, dyspeptic symptoms, delivery mode, and feeding patterns
(exclusive breastfeeding, formula, complementary feeding) were recorded. Additionally, specific IgE levels and eosinophil
counts in infants with allergic proctocolitis were evaluated. Participants with antibiotic use in the last two months were
excluded. Stool samples were obtained from 27 mothers in the healthy group (53%) and 71 mothers in the AP group (74%).
Results: Demographic and clinical characteristics of infants and mothers are summarized in Table 1. H. pylori positivity in
stool samples was observed in 12.5% of infants with AP and 17.6% of healthy controls (p > 0.05). Among mothers, H. pylori
positivity was found in 15.6% of the AP group and 7.7% of the healthy group (p > 0.05).
Conclusions: Our findings reveal that H. pylori prevalence in stool samples of infants with allergic proctocolitis and their
mothers was not significantly different from healthy controls. These results suggest that H. pylori may not play a prominent
role in the pathogenesis of allergic proctocolitis. Further studies are needed to investigate the potential role of gut microbiota
in pediatric allergic conditions.