Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

KARABURUN A. Ç., GÜNDOĞDU KARABURUN N., Ucucu U., DEMİRAYAK Ş.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.8, sa.8, ss.758-762, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2174/157018011796576097
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.758-762
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

In this study, some aryl naphtho[2,1-b] furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, H-1-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 mu g/mL.