Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes

KARABURUN A. Ç., GÜNDOĞDU KARABURUN N., Ucucu U., DEMİRAYAK Ş.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.8, no.8, pp.758-762, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.2174/157018011796576097
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.758-762
  • Eskisehir Osmangazi University Affiliated: No

Abstract

In this study, some aryl naphtho[2,1-b] furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, H-1-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 mu g/mL.