Myocardial infarction in young patients (<= 35 years of age) with systemic lupus erythematosus: a case report and clinical analysis of the literature

Korkmaz C., Cansu D. U., Kasifoglu T.

LUPUS, vol.16, no.4, pp.289-297, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1177/0961203307078001
  • Journal Name: LUPUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.289-297
  • Keywords: acute myocardial infarction, atherosclerosis, coronary aneurysm, coronary vasculitis, systemic lupus erythematosus, CORONARY-ARTERY-DISEASE, PREMATURE ATHEROSCLEROSIS, NEPHROTIC SYNDROME, VASCULITIS, WOMAN, ANTICOAGULANT, ANTIBODIES, RISK, MANIFESTATIONS, ANEURYSMS
  • Eskisehir Osmangazi University Affiliated: Yes


The present study aims to report a-20-year old girl with systemic lupus erythernatosus (SLE) who developed myocardial infarction (MI) and also aims to review acute myocardial infarction (AMI) in young SLE cases (:! 35 years) reported in the literature. We conducted a comprehensive review of the English literature from 1975 to 2006 to analyse data on MI in SLE patients who had developed AMI either at 35 or earlier. In 32 English articles, we identified 49 SLE patients, plus our case, with ANII. They consist of 41 female and nine male patients, their mean age being 24 +/- 6.4 years (range of 5-35). Disease duration varied between 0 and 13 years. The lag time between the onset of the SLE manifestations and development of AMI was 7.7 +/- 5.4 year (range of 1 month to 20.5 years). We divided the patients into three subgroups according to their coronary involvement type (Group I: normal coronary artery or coronary thrombosis (n = 16); Group II: coronary aneurysin/arteritis (n = 12); Group III: coronary atherosclerosis (n = 22)). The lag time between the onset of the SLE manifestations and development of MI in the subgroups showed variations: Group I < Group II < Group III. Both prevalence ofrenal involvement and steroid therapy were higher in patients with coronary atherosclerosis than were in Group I. There were one or more risk factors for atherosclerosis in 39 SLE patients. AMI in young SLE patients may be seen, albeit rare. We suggest that clinicians shculd have a low threshold for cardiac evaluation in patients with SLE. Also, traditional risk factors could be managed through preventive measures.